OECD221_Cd

TKTD model

Toxicokinetic assumptions

• The temperature, food density and external concentration (i.e. in the water) are constant
• The uptake rate is proportional to the surface area of the individual and to the external concentration
• The elimination rate k_e is proportional to the internal concentration

Toxicodynamic assumptions

• Effects are linked to the internal concentration c, scaled such that it has the dimension of an external concentration
• The stress s is absent (s=0) for concentrations less than c_0, and for larger concentrations equal to s=(c-c_0)/c_T
• The reproduction rate is multiplied by the embryo survival probability exp(-s)

Discussion

• The type of length in parameter L0 should correspond with that in parameter v, so structural length
• Read (compound) DEB parameters from prt_report_my_pet('Daphnia_magna')